Non-Rigid Registration to Capture Optic Nerve Head Variability
نویسندگان
چکیده
Glaucoma causes variations of the optic nerve head (ONH). We propose an approach to describe the inter subject variability of the ONH by dense deformation fields produced by non-rigid registration. Non-glaucoma but acquisition related variations are eliminated in a preprocessing step. Standard non-rigid registration was extended by a radial smoothing regularizer to preserve the ONH natural circular appearance and to enforce a physiological suitable mapping. The proposed approach captures successfully ONH variations.
منابع مشابه
Variability across the optic nerve head in scanning laser tomography.
AIM To characterise measurement variability in scanning laser tomography of the optic nerve head. METHODS 21 normal and 21 glaucoma subjects underwent same and separate day test-retest Heidelberg retina tomograph imaging by the same and different operators. RESULTS Rim area was most reproducible among parameters. Its variability tended to be highest temporally and increased (p<0.05) with te...
متن کاملClinical Applications of Optical Coherence Tomography in Ophthalmology
Assessment of the peripapillary nerve fiber layer and macular thickness can be determined in ophthalmology using optical coherence tomography (OCT). Decreased nerve fiber layer thickness and macular ganglion cell thickness in optic nerve ischemia have been correlated with visual field loss. OCT allows deep optic nerve head evaluation which helps understand pathophysiology of diseases. Furtherm...
متن کاملCan Coffee Improve Surgical Robot Accuracy?
Transnasal skull base and sinus surgery is often assisted via image guidance systems (e.g. the Brainlab Kolibri [1] – Fig. 1) which show the real-time locations of surgical instruments with respect to the 3D map provided by preoperative volumetric medical images. Image guidance systems often employ optical tracking to measure in real time the locations of both surgical instruments and the patie...
متن کاملEffect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography (OCT)
BACKGROUND In this paper we determined the benefits of image registration on estimating longitudinal retinal nerve fiber layer thickness (RNFLT) changes. METHODS RNFLT maps around the optic nerve head (ONH) of healthy primate eyes were measured using Optical Coherence Tomography (OCT) weekly for 30 weeks. One automatic algorithm based on mutual information (MI) and the other semi-automatic al...
متن کاملDifferential Effects of Elevated Hydrostatic Pressure on Gene Expression and Protein Phosphorylation in Optic Nerve Head Astrocytes
1.1 Primary Open Angle Glaucoma (POAG) Elevated intraocular pressure (IOP) is the most important risk factor in POAG. Typically affecting older adults, in POAG the IOP exceeds the level that is tolerated by that individual’s optic nerve head (ONH). However, many individuals with clinical ocular hypertension do not exhibit glaucomatous changes in the optic disk; whereas, some individuals will de...
متن کامل